MOTS-C
A peptide associated with mitochondria—the parts of cells that help produce energy. It is studied mostly in cell and metabolic research.
Whole vial: 10 mg Vial math ↓
Why people look it up
MOTS-C became popular as a possible 'exercise' or metabolism peptide after mouse studies reported effects on insulin sensitivity, physical performance, and weight-related biology.
Insulin sensitivity and metabolismANIMAL / PRECLINICAL EVIDENCE
Mouse experiments reported improved metabolic outcomes. Read source ↗
Exercise capacityANIMAL / PRECLINICAL EVIDENCE
Treatment improved physical performance in mice; human participants only had endogenous levels measured after exercise. Read source ↗
Human weight loss or anti-agingINSUFFICIENT EVIDENCE
Mouse treatment findings do not establish clinical benefits in people. Read source ↗
The labels show the evidence for each claim. Open a row for its source.
Dosage at a glance
Dosage source summary
- How often
- Every five days in one report
- Time on / time off
- 20-day period; breaks not stated.
- Route
- Subcutaneous in that report.
Three comparable lower/middle/higher examples are not established in the reviewed sources. One account, not a common-use range. It also described hives, bruising and itching.
These source amounts do not establish a safe human dose for a research vial.
Sources & individual reports
Source coverage: 1 reviewed public account. Not a community consensus.
Report 1 ↗First-person account
- Amount reported
- 5 mg each time
- How often reported
- every five days
- Reported duration / cycle
- 20 days
- Route (how it was taken)
- subcutaneous, as stated by poster
What the account says: Poster described hives, bruising, and prolonged itching. BPC-157, L-carnitine, and cardarine were also used, so perceived results cannot be attributed to MOTS-c.
Product match & source details
Product match: The research product and purity were not independently verified.
r/Peptides firsthand post · Posted: 2023-04-23 · Reviewed: 2026-10-03.
How much agreement is there? Only one directly checked account is shown. It cannot establish a common amount or cycle.
Public sources last reviewed: 2026-10-03. Product identity and reported results were not independently verified. Source method →
Evidence, sources & vial math
What the research actually showsHuman studies, evidence limits and mechanisms
What has actually been studied?
Experiments in mice show metabolic and exercise-related signals. A human exercise study measured the body's own MOTS-C response; it did not test MOTS-C treatment in people.
Evidence limits: Human studies cited here measured the body’s own MOTS-c during exercise; they do not establish benefits or dosing from administering this vial.
Product status: Research-vial listings are not FDA-approved medicines. Approved-use labels on this page refer only to the named finished prescription product.
Human research
Acute exercise and circulating mitochondrial-derived peptides 2021
What was found: Circulating MOTS-c showed an upward pattern after endurance exercise, but the group-by-time difference was not statistically significant (P = 0.17). Humanin did increase significantly. No MOTS-c was administered.
Main limit: Small exercise study measuring endogenous peptide, not dosing an external product.
Study setup and amounts
- Who
- Adults assigned to endurance exercise, resistance exercise, or control
- Number of participants
- 30
- Study design
- Randomized exercise comparison
- Route
- No MOTS-c administered; blood and muscle levels measured
- Amount studied
- No administered amount
- Frequency
- Single exercise session
- Duration
- Samples before, 30 minutes, and 3 hours after exercise
- Outcome measured
- Circulating and muscle mitochondrial-derived peptide levels
Study and prescription-product amounts describe those sources. They do not select an amount for an online research vial.
How researchers think it might work
MOTS-c is a peptide made from mitochondrial genetic material. Researchers study how its levels relate to exercise and metabolism.
Show scientific explanation
Human exercise studies measured naturally circulating MOTS-c; they did not administer a research-vial dose. Read supporting source ↗
Vial & syringe mathTurn the vial total and liquid volume into concentration and syringe units
Vial & syringe math
Change the vial total and final liquid volume to see what each U-100 syringe mark represents.
The starting 1 mL is a math example. Enter your final mixed volume to update the numbers.
100 U-100 syringe units = 1 mL. These results assume the labeled amount is evenly mixed through the final liquid volume.
Continue in the calculator →About this listingResearch-use-only status, seller names and additional background
A research material is not intended for human use. Its name or lab report does not establish suitability for a person. What research use only means →
Compiled by PeptideWhy · Scientific sources last checked 2026-10-03 · Editorial policy · Corrections